DUSP14 (N-term) Peptide
产品名称： DUSP14 (N-term) Peptide
英文名称： DUSP14 (N-term) Peptide
产品编号： P3290
产品价格： 0
产品产地： 台湾
品牌商标： Abnova
更新时间： null
使用范围： null
亚诺法生技股份有限公司（Abnova)
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- 邮编 : 11493
- 所在区域 : 台湾
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- 邮箱 : sales@abnova.com.tw
- Specification
- Product Description:
- Rabbit polyclonal antibody raised against synthetic peptide of DUSP14.
- Immunogen:
- A synthetic peptide (conjugated with KLH) corresponding to N-terminus of human DUSP14.
- Host:
- Rabbit
- Reactivity:
- Human, Mouse
- Form:
- Liquid
- Purification:
- Protein G purification
- Storage Buffer:
- In PBS (0.09% sodium azide)
- Storage Instruction:
- Store at 4°C. For long term storage store at -20°C.
Aliquot to avoid repeated freezing and thawing.
- Recommend Usage:
- ELISA (1:1000)
Western Blot (1:100-500)
Immunohistochemistry (1:50-100)
The optimal working dilution should be determined by the end user.
- Note:
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Publication Reference
- 1.
- Negative-feedback regulation of CD28 costimulation by a novel mitogen-activated protein kinase phosphatase, MKP6.
Marti F, Krause A, Post NH, Lyddane C, Dupont B, Sadelain M, King PD.J Immunol. 2001 Jan 1;166(1):197-206.
- Applications
- Western Blot (Tissue lysate)
- Western blot analysis of mouse bladder tissue lysate (35 ug/lane) with DUSP14 polyclonal antibody (Cat # PAB4142).
- Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections)
- Formalin-fixed and paraffin-embedded human hepatocellular carcinoma tissue reacted with DUSP14 polyclonal antibody (Cat # PAB4142) , which was peroxidase-conjugated to the secondary antibody, followed by AEC staining.
This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.
- Entrez GeneID:
- 11072
- Protein Accession#:
- NP_008957;O95147
- Gene Name:
- DUSP14
- Gene Alias:
- MKP-L,MKP6
- Gene Description:
- dual specificity phosphatase 14
- Omim ID:
- 606618
- Gene Ontology:
- Hyperlink
- Gene Summary:
- In addition to antigen recognition by the T-cell receptor, T-cell activation requires a second signal from a costimulatory receptor, such as CD28 (MIM 186760), which interacts with B7-1 (CD80; MIM 112203) and B7-2 (CD86; MIM 601020) ligands on antigen-presenting cells. CD28 costimulation induces transcription of interleukin-2 (IL2; MIM 147680) and stabilizes newly synthesized IL2 through the activation of mitogen-activated protein kinases (MAPKs), such as ERK (e.g., MAP2K4; MIM 601335) and JNK (see MIM 601158), and the subsequent creation of AP1 transcription factor (see MIM 165160). DUSP14 is a negative regulator of CD28 signaling.[supplied by OMIM
- Other Designations:
- MKP-1 like protein tyrosine phosphatase,OTTHUMP00000164064,OTTHUMP00000164065
- Gene Pathway